Effects of an Angiotensin-Converting Enzyme Inhibitor, Lisinopril, on Cerebral Blood Flow Autoregulation in Healthy Volunteers
- 1 September 1993
- journal article
- clinical trial
- Published by Wolters Kluwer Health in Journal of Cardiovascular Pharmacology
- Vol. 22 (3) , 373-380
- https://doi.org/10.1097/00005344-199309000-00005
Abstract
The effects of a single oral dose (20 mg) of lisinopril on systemic, carotid (pulsed Doppler), and cerebral (middle cerebral artery, transcranial Doppler) hemodynamics have been investigated over an 8-h period in eight healthy volunteers in a double-blind placebo-controlled crossover study. In addition, cerebral vasodilatory reserve was measured (acetazolamide test). Lisinopril did not affect systemic hemodynamics but it increased both common carotid artery blood flow (+ 26.2%, pKeywords
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