Circulating intercellular adhesion molecule 1 as a new activity marker in patients with systemic lupus erythematosus

1 April 1993

journal article
Published by Springer Nature in Journal of Molecular Medicine

Vol. 71 (4) , 299-304
https://doi.org/10.1007/bf00184731

Abstract

To determine the value of soluble intercellular adhesion molecule 1 (sICAM-1) as a measure of disease activity in patients with systemic lupus erythematosus (SLE), 25 patients with SLE were studied in an active and in a less active state. Disease activity was assessed according to the New York Hospital for Special Surgery System (NYHSS) score. The levels of sICAM-1 were significantly higher in an active than in a less active state of the disease (Pr=0.3412 (Pr=0.6620 (Pr=0.6792, P3. Our data suggest that sICAM-1 reflects disease activity in patients with SLE, but this parameter per se should not be used to guide the therapeutic decision in SLE patients suspected of suffering from exacerbation of disease.

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