Clinical Studies and Thrombin Generation in Patients Homozygous or Heterozygous for the G20210A Mutation in the Prothrombin Gene
- 1 August 1998
- journal article
- clinical trial
- Published by Wolters Kluwer Health in Arteriosclerosis, Thrombosis, and Vascular Biology
- Vol. 18 (8) , 1287-1291
- https://doi.org/10.1161/01.atv.18.8.1287
Abstract
—A genetic variation in the prothrombin gene, the G→A transition at nucleotide 20210, is a risk factor for venous thrombosis in heterozygotes and is associated with increased prothrombin ac...Keywords
This publication has 26 references indexed in Scilit:
- The Routine Determination of the Endogenous Thrombin Potential, First Results in Different Forms of Hyper- and HypocoagulabilityThrombosis and Haemostasis, 1997
- Elevated Levels of Prothrombin Activation Fragment 1+2 in Plasma from Patients with Heterozygous Arg506 to Gin Mutation in the Factor V Gene (APC-Resistance) and/or Inherited Protein S DeficiencyThrombosis and Haemostasis, 1996
- Mutation in blood coagulation factor V associated with resistance to activated protein CNature, 1994
- Normalization of markers of coagulation activation with a purified protein C concentrate in adults with homozygous protein C deficiencyBlood, 1993
- Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C.Proceedings of the National Academy of Sciences, 1993
- Homozygous protein S deficiency in an infant with purpura fulminansThe Journal of Pediatrics, 1990
- Hemostatic enzyme generation in the blood of patients with hereditary protein C deficiencyBlood, 1988
- The pathophysiology of the prethrombotic state in humans: insights gained from studies using markers of hemostatic system activationBlood, 1987
- Homozygous Protein C Deficiency Manifested by Massive Venous Thrombosis in the NewbornNew England Journal of Medicine, 1984
- INHERITED PROTEIN C DEFICIENCY AND COUMARIN-RESPONSIVE CHRONIC RELAPSING PURPURA FULMINANS IN A NEWBORN INFANTThe Lancet, 1983