EFFECT OF HORMONES UPON REGRESSION OF MUSCLE ATROPHY OF NERVOUS ORIGIN

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Abstract
The effect of various hormones upon the regression of muscle atrophy of nervous origin has been studied in young rats. Unilateral nerve lesion was performed by crushing the obturator, sciatic and femoral nerves intrapclvically— a procedure which resulted in marked atrophy of the triceps surao muscle. Subsequent to complete functional recovery, treatment with hormones was initiated to see whether it would alter the course of the regression of the muscular atrophy. STH, methyltestosterone, estradiol and thyroxin promote the rate of regression subsequent to reinnervation. Treatment with cortisol or 17-ethyl-19-nortestosterone, at the high dose levels used, exerts an opposite effect, while desoxycorticosterone has no influence. From the results obtained in these experiments it can be concludedthat, under certain experimental conditions, catabolic hormones, e.g., thyroxin and estradiol, can promote a circumscribed anabolic process, such as regression of muscle atrophy.

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