Continuous Solid-Phase Synthesis and Disulfide Cyclization of Peptide−PNA−Peptide Chimeras
- 16 October 2002
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 4 (23) , 4013-4016
- https://doi.org/10.1021/ol026676b
Abstract
Chelator peptides were extended from the N-terminus of peptide nucleic acid (PNA) dodecamers, which in turn were extended from the N-termini of disulfide-bridged peptide ligand analogues, using Fmoc coupling for all residues. The cysteine thiols were cyclized on a solid support, either before or after PNA extension. This simplified synthetic approach might allow preparation of a variety of multipeptide disulfide-bridged PNA chimeras. [structure: see text]Keywords
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