Separation of Aromatic Amine Isomers by High-Pressure Liquid Chromatography on Cadmium-Impregnated Silica Gel Columns
- 1 April 1974
- journal article
- Published by Oxford University Press (OUP) in Journal of Chromatographic Science
- Vol. 12 (4) , 191-196
- https://doi.org/10.1093/chromsci/12.4.191
Abstract
High-speed liquid chromatographic separation of chloroaniline and toluidine isomers was accomplished in six minutes using cadmium-impregnated silica gel. Efficiency and capacity factors were found to depend on the amount of cadmium impregnated. The increase in retention time and selectivity in cadmium-impregnated columns was related to the basicity of the amines and the steric hindrance of the ortho isomers. Detection limits were 1 ng for the ortho isomers and 3–5 ng for the meta and para isomers.Keywords
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