MUC1 in secretory phase endometrium: expression in precisely dated biopsies and flushings from normal and recurrent miscarriage patients

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Abstract
MUC1 is a cell-surface and secretory product of endometrial epithelium. Immunohistoehemical studies carried out using two different antibodies to the mucin-type tandem repeat region of MUC1 indicate a cell-surface location in proliferative phase glands, with intracellular deposits accumulating in the early secretory phase. Commencing 3–4 days after the luteinizing hormone (LH) peak and continuing into the late secretory phase, secretory MUC1 appears in gland lumens. Uterine flushings were collected as a function of time after the LH peak and were analysed using a two-site enzyme-linked immunosorbent assay for MUC1. Low but measurable concentrations were observed up to day 7, while on days 7–13 much higher values were obtained. In women suffering from recurrent spontaneous miscarriage, the concentration of MUC1 in flushings wassignificantly lower than in the controls on day LH+10. Lower values were also observed on days 7 and 13. Reduced epithelial secretory function and a resultant change uterine fluid composition are features of endometrium from recurrent miscarriage patients.

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