Histamine-Releasing Effect of a Corticotrophin Derivative
- 1 January 1977
- journal article
- research article
- Published by S. Karger AG in Pharmacology
- Vol. 15 (2) , 134-142
- https://doi.org/10.1159/000136673
Abstract
The histamine-liberating properties of a synthetic polypeptide (an alkyl-prolyl derivative of β1–19-corticotrophin) were investigated under a variety of experimental conditions. It was found to be more potent in this respect than Compound 48/80, Melittin and Triton X-100. The degree of cell destruction observed in conjunction with the release of histamine induced by C 44 680-Ba suggests that the mode of action of the substance more closely resembles that of Compound 48/80 than that of Triton.Keywords
This publication has 0 references indexed in Scilit: