Estrogen receptor- and aromatase-deficient mice provide insight into the roles of estrogen within the ovary and uterus
- 31 May 2001
- journal article
- review article
- Published by Wiley in Molecular Reproduction and Development
- Vol. 59 (3) , 336-346
- https://doi.org/10.1002/mrd.1039
Abstract
Estrogen receptor (ER)‐ (α, β, and both α and β) and aromatase (Ar) knockout (KO) mice have been created to assess the biological effects of estrogens. This review article discusses the ovarian and uterine phenotypes of these mice. The data obtained have confirmed some older inferences about how the steroid acts, but have also revealed some unexpected aspects of estrogen action. Mol. Reprod. Dev. 59:336–346, 2001.Keywords
This publication has 71 references indexed in Scilit:
- Differential Expression of Estrogen Receptor-α and -β and Androgen Receptor in the Ovaries of Marmosets and HumansBiology of Reproduction, 2000
- Estrogen Targets Genes Involved in Protein Processing, Calcium Homeostasis, and Wnt Signaling in the Mouse Uterus Independent of Estrogen Receptor-α and -βJournal of Biological Chemistry, 2000
- Immunolocalisation of oestrogen receptor beta in human tissuesJournal of Molecular Endocrinology, 2000
- Disruption of Sexual Behavior in Male Aromatase-Deficient Mice Lacking Exons 1 and 2 of thecyp19GeneBiochemical and Biophysical Research Communications, 1998
- ERβ: Identification and characterization of a novel human estrogen receptorFEBS Letters, 1996
- Cloning of a novel receptor expressed in rat prostate and ovary.Proceedings of the National Academy of Sciences, 1996
- Effects of a non-steroidal pure antioestrogen, ZM 189,154, on oestrogen target organs of the rat including bonesJournal of Endocrinology, 1994
- Sequence and Expression of Human Estrogen Receptor Complementary DNAScience, 1986
- Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-ANature, 1986
- Further characterization of the second oestrogen-binding species of the rat granulosa cellJournal of Endocrinology, 1984