Thermo- and pH-Responsive Biodegradable Poly(α-N-substituted γ-glutamine)s
- 1 August 2003
- journal article
- research article
- Published by American Chemical Society (ACS) in Biomacromolecules
- Vol. 4 (5) , 1132-1134
- https://doi.org/10.1021/bm034123y
Abstract
New double stimuli-responsive poly(α-N-substituted γ-glutamine) has been developed, which was synthesized by the reaction of poly(γ-glutamic acid) with amino alcohols. Appropriate combinations of the amino alcohols provided the biodegradable poly(amino acid) exhibiting a sharp lower critical solution temperature (LCST) in water. Furthermore, the phase transition temperature was highly sensitive to pH changes.Keywords
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