In Vitroandin VivoAssessement of the Antimalarial Activity of Sergeolide

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Abstract
The antimalarial activity of sergeolide (a quassinoid from Picrolemma pseudocoffea) was investigated both, in vitro on Plasmodium falciparum cultures and in vivo through a classical test of schizontocidal action against Plasmodium berghei in mice. Sergeolide showed a very strong antiplasmodial activity in vitro as well as in vivo. Low concentrations (0.006 µg/ml) were able to fully inhibit the in vitro growth of chloroquine-sensitive and resistant strains of P. falciparum. Small amounts (0.26 mg/kg/day) markedly reduced the virulence of experimentally induced P. berghei infection in mice. However, sergeolide, because of its high toxicity (LD 50: 1.8 mg/kg), does not seem, in its present form to be useful for malaria curative treatment.

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