Analysis of sonographic features in the differentiation of fibroadenoma and invasive ductal carcinoma.

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Abstract
The purpose of this study was to determine the predictive power of sonographic tumor descriptors in the differentiation of fibroadenoma from invasive ductal carcinoma of the breast.Three hundred thirty-six tumors (142 fibroadenomas and 194 invasive ductal carcinomas) of the breast diagnosed using sonography were prospectively recorded with respect to the shape, contour, echo texture, echogenicity, sound transmission, and surrounding tissue of the tumors. Evaluation included odds and odds ratios of single sonographic features as well as sensitivity, specificity, and positive and negative predictive values of combinations of features. Tumor descriptors were also evaluated using multiple logistic regression analysis after adjustment for age and clinical examination.Irregular shape and contour, extensive hypoechogenicity, shadowing, echogenic halo, and distortion of surrounding tissue were the findings with the highest predictive value of malignancy. A thin echogenic pseudocapsule was the most important sonog...

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