ACUTE MYELOGENOUS LEUKEMIA AS A LATE COMPLICATION OF MULTIMODALITY THERAPY FOR HODGKINS-DISEASE

  • 1 January 1977
    • journal article
    • research article
    • Vol. 141  (5) , 249-251
Abstract
Progressive thrombocytopenia developed in a patient following the completion of total lymphoid irradiation and combination chemotherapy for Hodgkin''s disease. Thorough evaluation eventually yielded a diagnosis of acute myelogenous leukemia (AML). Previous workers suggested that the development of thrombocytopenia with a hypoplastic marrow following total lymphoid irradiation indicated recurrent Hodgkin''s disease. When the combination of cytopenias and hypoplastic marrow is recognized these workers recommended early combination chemotherapy. Recent data suggest a 1300-fold increase in the risk of AML following multimodality therapy for Hodgkin''s disease. A careful search for AML should be conducted in patients with deteriorating hematologic parameters following therapy for Hodgkin''s disease and this search should include sampling bone marrow outside irradiated areas.

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