Transforming growth factor beta 1 as a prognostic factor in pulmonary adenocarcinoma.
Open Access
- 1 December 1994
- journal article
- research article
- Published by BMJ in Journal of Clinical Pathology
- Vol. 47 (12) , 1098-1100
- https://doi.org/10.1136/jcp.47.12.1098
Abstract
AIMS--To evaluate the efficacy of transforming growth factor beta (TGF-beta) for the prognosis of pulmonary adenocarcinoma. METHODS--TGF-beta was detected immunohistochemically using the avidin-biotin-peroxidase complex technique in resected pulmonary adenocarcinomas from 88 patients. RESULTS--Of the 88 patients, 39 were TGF-beta negative and 45 TGF-beta positive. The five year survival rate was 56% for the TGF-beta negative and 16% for the TGF-beta positive group. CONCLUSIONS--TGF-beta can be used as a prognostic factor in pulmonary adenocarcinoma.Keywords
This publication has 13 references indexed in Scilit:
- Transforming growth factor beta1 in ductal carcinoma in situ and invasive carcinomas of the breastEuropean Journal Of Cancer, 1992
- Transforming growth factor beta stimulates mammary adenocarcinoma cell invasion and metastatic potential.Proceedings of the National Academy of Sciences, 1990
- Immunocytochemically Detectable TGF-β Associated with Malignancy in Thyroid Epithelial NeoplasiaGrowth Factors, 1990
- TRANSFORMING GROWTH FACTOR-BETA INHIBITION OF EPITHELIAL-CELL PROLIFERATION LINKED TO THE EXPRESSION OF A 53-KDA MEMBRANE-RECEPTOR1989
- Latent high molecular weight complex of transforming growth factor beta 1. Purification from human platelets and structural characterization.Journal of Biological Chemistry, 1988
- The TGF-β family of growth and differentiation factorsCell, 1987
- MUTATION-RATE OF NORMAL AND MALIGNANT HUMAN-LYMPHOCYTES1987
- Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures.Journal of Histochemistry & Cytochemistry, 1981
- Increasing incidence of adenocarcinoma of the lungCancer, 1981
- Autocrine Secretion and Malignant Transformation of CellsNew England Journal of Medicine, 1980