Twenty‐Four Hour Variation in Flow and Composition of Leg Lymph in Normal Men

Abstract
The twenty‐four hour variation in concentration and output of total protein, lactate dehydrogenase and alkaline phosphatase has been studied in the peripheral lymph from the legs of 5 healthy volunteers over a period of five days. The highest concentration of these proteins was found in lymph collected during the first two hours after a night's rest. During the day a continuous decrease in concentration occurred without any direct correlation to lymph flow. The variation in lymph protein concentration between early morning and late day was about 40 %, lactate dehydrogenase and alkaline phosphatase about 90% and 45o, respectively.