Antidandruff shampoos and the stratum corneum

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Abstract
The clinical efficacy of antidandruff shampoos containing antifungal agents is correlated with their anti-Malassezia activity. Other ingredients of the shampoos also affect the efficacy and tolerability of the treatments. This study was conducted to quantify the effect of eight proprietary antidandruff shampoos on the human stratum corneum. Corneosurfametry and squamometry were used to rate the interaction between the shampoos and the stratum corneum. Significant differences in mildness were disclosed between some test shampoos and SLES-7EO selected as a mild reference surfactant. The activity against corneocyte clumping also showed significant differences among the test products. It is concluded that the formulation of shampoos for dandruff should not be overlooked.

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