Rapid Treatment of Early Syphilis with Multiple Injections of Mapharsen

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Abstract
275 unselected cases of syphilis were treated with repeated injns. of mapharsen. The first series of 134 cases were given a total dose ranging from 1-1.2 g. of mapharsen spread over a period of time, but this method was discontinued because of the death of 2 patients from hemorrhagic encephalitis. Since patients with neuro-syphilis who had been treated with malaria apparently withstood larger doses of mapharsen than did afebrile patients, a new method involving a smaller dosage (0.6-0.84 g.) given every other day with the intervening day left for the injn. of a fever-producing typhoid vaccine. Favorable results were obtained in 86.3% of the cases treated with the larger dosage but only in 76.9% of the 141 cases treated with the combined fever and mapharsen method. However, with the latter method there were no deaths from hemorrhagic encephalitis. Of 6 cases which were shown by follow-up examinations to have persistently positive blood Wassermanns, 1 was retreated and the other 5 allowed to go with no further treatment as the titre was slowly declining.

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