Esophageal Ulceration Associated with Oral Theophylline

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Abstract
To the Editor: A number of medications have been shown to cause erosion and ulceration when lodged in the esophagus, including aspirin, emepronium bromide, slow-release potassium preparations, tetracycline, doxycycline, and clindamycin.1 We recently observed a patient with esophageal erosion due to an extended-release theophylline preparation.The patient was a 30-year-old army physician who was on temporary duty with an infantry unit on a field-training exercise in the Philippine Islands. He had mild asthma, which was well controlled with sustained-action theophylline tablets (Theo-Dur), 400 mg taken twice daily (12 mg per kilogram of body weight per day), and occasional aerosol albuterol. . . .

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