Plasma Erythropoietin Levels in Mice during the Growth Period

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Abstract
Plasma erythropoietin (erythropoiesis stimulating factor(s), ESF), PCV [packed cell volume] and body weight were measured in normal mice from birth until the age of 70 d [days]. Low but detectable ESF activity was present at birth, followed by undetectable levels 12-48 h after birth. Thereafter the ESF level rapidly increased. Peak levels were obtained 15-20 d after birth. During the same phase an increased growth velocity occurred, coincident with decreased PCV levels. A fall to undetectable levels in plasma ESF activity coincided with deceleration of growth 40-50 d after birth. In small litters (4 pups/litter) growth velocity and PCV levels were significantly higher than in large litters (16 pups/litter) 8 and 15 d after birth. The plasma ESF activity did not differ between the 2 groups. Prohibiting suckling for 16 h did not change the plasma ESF level. Growth may directly or indirectly stimulate ESF production.