Enhancement of Alcohol Withdrawal Seizures with 6‐Hydroxy dopamine
- 1 December 1978
- Vol. 19 (6) , 603-609
- https://doi.org/10.1111/j.1528-1157.1978.tb05040.x
Abstract
The relationship between central catecholamine neurons and alcohol withdrawal seizures was studied in rats pretreated with 6-hydroxydopamine to selectively destroy the central catecholamine nerve terminals. The alteration of alcohol withdrawal seizures was manifested by a higher percentage of the rats developing the seizures, an earlier onset of seizures and a greater severity of seizure activity. Seizure status was exhibited in 25% of the 6-hydroxydopamine-treated rats.Keywords
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