Epstein‐Barr virus genomic sequences and specific antibodies in cerebrospinal fluid in children with neurologic complications of acute and reactivated EBV infections

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Abstract
Four children with infectious mononucleosis (IM) and one with reactivated Epstein‐Barr virus (EBV) infection had concomitant central nervous system disorders. Cerebrospinal fluid (CSF) samples from all five patients contained EBV genomic sequences and EBV‐specific antibodies in the neurologic stage, but not during convalescence. Cerebrospinal fluid from two non‐neurologic IM patients had neither EBV DNA nor EBV antibodies. The EBV‐positive CSF of the five with neurological disorders were aseptic in culture and all negative for other human herpesvirus DNAs and antibodies: herpes simplex virus types 1 and 2, cytomegalovirus, varicella‐zoster virus, and human herpesvirus 6. Epstein‐Barr virus DNA and EBV antibodies were not detected in the CSF of 17 EBV‐seropositive patients with mumps meningitis, rubella encephalitis, unknown febrile convulsion, or partial epilepsy. It is suggested that EBV plays a causal role in neurologic manifestations in patients with acute and reactivated EBV infections, through direct viral invasion and immunopathological reactions.