Effects of Sodium Diphenylhydantoinate upon Isolated Small Intestine of the Rabbit
- 1 October 1955
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 90 (1) , 173-176
- https://doi.org/10.3181/00379727-90-21972
Abstract
Addition of sodium diphenylhydantoinate (Dilantin) to a solution bathing the isolated small intestine of the rabbit resulted in a rapid decrease in the amplitude of contractions and a fall in tone. Resultant concentrations of Dilantin ranged between 0.5 and 8 mg%. The rate of contractions was slowed and with higher concentrations the contractions were arrested. These effects of Dilantin were rapidly reversible and were not due to its alkalinity. Clinical implications of these findings are discussed.Keywords
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