Inflammatory responses to intraocularly injected interleukin 1

Publisher Website
Google Scholar
Abstract
Intraocular injection of highly purified human interleukin 1 into the anterior chamber of the rabbit eye resulted in the accumulation of inflammatory cells. Peak cellular infiltration occurred at 4 hr and cells were still present at 24h. Examination of ocular blood vessels in II-1 - injected eyes revealed no abnormalities. IL-1 had no effect on the protein content of the aqeous humour confirming that this monokine has no direct action on the blood-aqUeous barrier. Comparison of the potency of IL-1 as a chemoattractant with the 5-lipoxygenase product, leukotriene B4 demonstrated that the former agent was more active by several orders of magnitude.