LYMPHOCYTOTOXIC ANTIBODY IN MULTIPLE-SCLEROSIS - ACTIVITY AGAINST T-CELL SUBSETS AND CORRELATION WITH DISEASE-ACTIVITY

  • 1 January 1983
    • journal article
    • research article
    • Vol. 53  (1) , 133-139
Abstract
The presence of lymphocytotoxic activity in multiple sclerosis (MS) sera was confirmed using techniques designed to eliminate possible sources of erroneous conclusion not considered in previous studies. This activity was further characterized and found to be non-dialyzable and complement dependent, and, therefore, presumably to be an antibody. This lymphocytotoxic antibody (LCA) is found only in those patients with active or progressive disease, and appears to be preferentially directed against the suppressor subset of T cells, as defined by monoclonal antibodies. The LCA may play a role in the pathogenesis of acute exacerbation of MS.