Increased arterial oxygen content -- an important compensatory mechanism in chronic moderate heart failure
- 1 May 1991
- journal article
- research article
- Published by Oxford University Press (OUP) in Cardiovascular Research
- Vol. 25 (5) , 384-390
- https://doi.org/10.1093/cvr/25.5.384
Abstract
Study objective – The aim was to determine whether mere is a compensatory increase in arterial oxygen content to a hypokinetic circulation in ambulant patients with chronic moderate heart failure caused by dilated cardiomyopathy. Design – Central haemodynamics, arterial oxygen content, arterial haemoglobin concentration, arterial oxygen saturation, and blood gases were measured during a 6 min supine exercise test on a symptom related submaximal workload. At rest, total body haemoglobin was determined. Patients – 19 patients with chronic stable moderate heart failure caused by dilated cardiomyopathy, treated with diuretics and digoxin, were studied. Measurements and main results – During exercise arterial oxygen content correlated inversely with the cardiac index (r = 0.66, pConclusions – A hypokinetic circulation during daily living induces an increase in arterial oxygen content in patients with chronic stable moderate heart failure caused by dilated cardiomyopathy. Renal hypoperfusion may play a role in stimulating the erythropoiesis and exertional hyperventilation in raising arterial oxygen saturation.Keywords
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