Polycystin Expression in the Kidney and Other Tissues: Complexity, Consensus and Controversy
- 31 July 2000
- journal article
- review article
- Published by S. Karger AG in Nephron Experimental Nephrology
- Vol. 8 (4-5) , 208-214
- https://doi.org/10.1159/000020670
Abstract
PKD1, the major gene mutated in autosomal dominant polycystic kidney disease, was identified in 1994, and fully sequenced in 1995. The protein which it encodes, polycystin-1, is the first member of a new family of proteins, whose functions presently remain unclear. This review seeks to highlight the difficulties researchers studying polycystin-1 have faced and to summarize the current areas of consensus and controversy between different groups, particularly with regard to the expression pattern, subcellular location and biochemical characterization of polycystin-1. Where relevant, more recent data regarding polycystin-2, the protein encoded by PKD2, will also be discussed.Keywords
This publication has 6 references indexed in Scilit:
- Late onset of renal and hepatic cysts in Pkd1-targeted heterozygotesNature Genetics, 1999
- Somatic Inactivation of Pkd2 Results in Polycystic Kidney DiseaseCell, 1998
- Perinatal lethality with kidney and pancreas defects in mice with a targetted Pkd1 mutationNature Genetics, 1997
- Homo- and heterodimeric interactions between the gene products of PKD1 and PKD 2Proceedings of the National Academy of Sciences, 1997
- Polycystin:In vitrosynthesis,in vivotissue expression, and subcellular localization identifies a large membrane-associated proteinProceedings of the National Academy of Sciences, 1997
- Polycystin, the polycystic kidney disease 1 protein, is expressed by epithelial cells in fetal, adult, and polycystic kidney.Proceedings of the National Academy of Sciences, 1996