Cutaneous Basophilic Hypersensitivity: A New Interpretation of the Jones-Mote Reaction

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Abstract
A type of delayed skin reaction which occurs transiently after immunization with soluble protein antigens alone or in incomplete Freund's adjuvant is well known (1, 2); its relationship to classic delayed (tuberculin) hypersensitivity, however, has been controversial. Raffel and Newel (3) concluded that the two reactions are different and suggested for historical reasons that the former be termed “Jones-Mote” hypersensitivity to distinguish it from classic delayed hypersensitivity produced by antigens in complete Freund's adjuvant (i.e., containing tubercle bacilli). This distinction has in general not been observed, and a current tendency is to consider Jones-Mote reactivity simply a milder form of classic delayed hypersensitivity (4, 5). Because of the apparent confusion associated with this reaction, we investigated Jones-Mote hypersensitivity with regard both to its antigenic requirements and its histologic features. We here present clear evidence that the Jones-Mote reaction is a distinct form of immunologic response, which is distinguishable on the one hand from delayed hypersensitivity and on the other from the classic antibody-mediated reactions such as anaphylaxis or the Arthus reaction.

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