Dispersion of Fluid Materials in Intracerebral Injections

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Abstract
Controlled clinical studies were conducted on the dispersion of fluid materials containing a radio-opaque marker in conjunction with injection lobotomy and chemopallidectomy. Regardless of the material, volume, or rate of injection, dispersion occurs along "paths of least resistance" which may be uncontrollable and unpredictable. When small volumes (less than 1 cc) of material are injected through a long, small bore needle, dispersion upward along the needle tract invariably occurs. When larger volumes of fluid material (2 to 15 cc) are similarly employed in intracerebral injection, there is constant appearance of the media in the subarachnoid space. These observations are confirmed by cadaver studies. For these reasons the use of potentially toxic or harmful agents for intracerebral injection seems unwise. Reference is made to sparse literature on this subject.
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