Modulation of the antigen transport machinery TAP by friends and enemies
- 6 December 2005
- journal article
- review article
- Published by Wiley in FEBS Letters
- Vol. 580 (4) , 1156-1163
- https://doi.org/10.1016/j.febslet.2005.11.048
Abstract
The transporter associated with antigen processing (TAP) is a key factor of the major histocompatibility complex (MHC) class I antigen presentation pathway. This ABC transporter translocates peptides derived mainly from proteasomal degradation from the cytosol into the ER lumen for loading onto MHC class I molecules. Manifold mechanisms have evolved to regulate TAP activity. During infection, TAP expression is upregulated by interferon-gamma. Furthermore, the assembly and stability of the transport complex is promoted by various auxiliary factors. However, tumors and viruses have developed sophisticated strategies to escape the immune surveillance by suppressing TAP function. The activity of TAP can be impaired on the transcriptional or translational level, by enhanced degradation or by inhibition of peptide translocation. In this review, we briefly summarize existing data concerning the regulation of the TAP complex.Keywords
This publication has 99 references indexed in Scilit:
- Exploring the minimal functional unit of the transporter associated with antigen processingFEBS Letters, 2005
- The murine gamma‐herpesvirus‐68 MK3 protein causes TAP degradation independent of MHC class I heavy chain degradationEuropean Journal of Immunology, 2004
- Model for the Interaction of Gammaherpesvirus 68 RING-CH Finger Protein mK3 with Major Histocompatibility Complex Class I and the Peptide-Loading ComplexJournal of Virology, 2004
- Bovine herpesvirus 1 interferes with TAP-dependent peptide transport and intracellular trafficking of MHC class I molecules in human cellsArchiv für die gesamte Virusforschung, 2003
- A Single-nucleotide Deletion Leads to Rapid Degradation ofTAP-1 mRNA in a Melanoma Cell LinePublished by Elsevier ,2003
- Tapasin Interacts with the Membrane-spanning Domains of Both TAP Subunits and Enhances the Structural Stability of TAP1·TAP2 ComplexesPublished by Elsevier ,2002
- Cis elements for transporter associated with antigen-processing-2 transcription: two new promoters and an essential role of the IFN response factor binding element in IFN-γ-mediated activation of the transcription initiatorInternational Immunology, 2002
- Assembly and Antigen-Presenting Function of MHC Class I Molecules in Cells Lacking the ER Chaperone CalreticulinImmunity, 2002
- Functional expression and purification of the ABC transporter complex associated with antigen processing (TAP) in insect cellsFEBS Letters, 1994
- An adenovirus type 2 glycoprotein blocks cell surface expression of human histocompatibility class I antigensCell, 1985