Plasma Antithrombin Activity: A Comparative Study in Normal and Diseased Animals

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Abstract
Total progressive antithrombin activity was significantly below normal in dogs with DIC [disseminated intravascular coagulation] and in aged Syrian hamsters with atrial thrombosis and consumption coagulopathy. It was normal in healthy dogs with 3 types of inherited hemostatic defects: hemophilia A, VWD [von Willebrand''s disease] and TT. These findings parallel those reported for humans with chronic diseases such as malignancy, thromboembolism and DIC, and exemplify the potential of spontaneous diseases in animals as models for the study of human diseases.

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