Motility- and blood flow-dependent absorption of amino acids in canine small intestine

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Abstract
A relationship between L-phenylalanine and L-serine absorption, intestinal motility and blood flow was studied with a canine in situ isolated jejunal loop in acute experiments and chronic preparations in conscious dogs. During spontaneous rhythmic contractions and after mechanical and pharmacological stimuli, rhythmic changes in blood flow, related to intestinal contractions were observed. They had no bearing on mean blood flow or absorption when they did not occur together with tonic contractions. The tonic contractions resulted in a prolonged decrease in jejunal blood flow and diminished amino acid absorption rate. Absorption and motility index, and blood flow and motility were negatively correlated. There was a positive rectilinear correlation between intestinal blood flow and absorption, regardless of whether changes in blood flow resulted from the increase in motility or were induced by intestinal artery occlusion. Changes in amino acid absorption during increased motility probably depend on changes in blood flow. This relationship may be important in clinical syndromes with hypermotility.

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