Dietary self-selection following subdiaphragmatic vagotomy in the white rat

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Abstract
Female Wistar rats (19) were employed in a self-selection-of-diet study assessing the effects of vagotomy on macronutrient consumption. Nutrients offered were a 30% sucrose solution, a 15% casein hydrolysate solution and olive oil. Noncaloric bulk, vitamins and water were allowed. Bilaterally, subdiaphragmatically vagotomized rats showed a significant decrement in carbohydrate ingestion and daily total caloric intake (P < .05 in both comparisons). Fat and protein intakes were unreliably altered. The vagus nerve probably relays glucose absorption and/or storage information from the periphery to the brain (perhaps lateral hypothalamus), and hence, vagotomy produces carbohydrate-intake decrements, specifically. The decrement could also be explained as resulting from efferent effects of vagotomy such as decreased gut hormonal release.

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