Expanding chemical biology of 2-oxoglutarate oxygenases
Top Cited Papers
- 1 March 2008
- journal article
- Published by Springer Nature in Nature Chemical Biology
- Vol. 4 (3) , 152-156
- https://doi.org/10.1038/nchembio0308-152
Abstract
Beyond established roles in collagen biosynthesis, hypoxic signaling and fatty acid metabolism, recent reports have now revealed roles for human 2-oxoglutarate–dependent oxygenases in histone and nucleic acid demethylation and in signaling protein hydroxylation. The emerging role of these oxygenases in enabling a multiplicity of histone modifications has some analogy with their role in enabling structural diversity in secondary metabolism.Keywords
This publication has 31 references indexed in Scilit:
- The Obesity-AssociatedFTOGene Encodes a 2-Oxoglutarate-Dependent Nucleic Acid DemethylaseScience, 2007
- ASB4 Is a Hydroxylation Substrate of FIH and Promotes Vascular Differentiation via an Oxygen-Dependent MechanismMolecular and Cellular Biology, 2007
- Structural basis of the recognition of a methylated histone tail by JMJD2AProceedings of the National Academy of Sciences, 2007
- Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificityNature, 2007
- A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult ObesityScience, 2007
- The most versatile of all reactive intermediates?Nature Chemical Biology, 2007
- Chromatin Modifications and Their FunctionCell, 2007
- Posttranslational hydroxylation of ankyrin repeats in IκB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)Proceedings of the National Academy of Sciences, 2006
- Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNAThe EMBO Journal, 2006
- Collagens, modifying enzymes and their mutations in humans, flies and wormsTrends in Genetics, 2004