Effect of casopitant, a novel NK-1 antagonist, on the pharmacokinetics of dolasetron and granisetron
Open Access
- 10 February 2009
- journal article
- Published by Springer Nature in Supportive Care in Cancer
- Vol. 17 (9) , 1187-1193
- https://doi.org/10.1007/s00520-008-0572-4
Abstract
The objective of this study was to characterize the impact of casopitant, a novel neurokinin-1 receptor antagonist under investigation for the prevention of postoperative and chemotherapy-induced nausea and vomiting, on the pharmacokinetics of the commonly prescribed 5-hydroxytryptamine receptor 3 receptor antagonists, dolasetron or granisetron.Keywords
This publication has 26 references indexed in Scilit:
- Impact of casopitant, a novel NK-1 antagonist, on the pharmacokinetics of ondansetron and dexamethasoneSupportive Care in Cancer, 2009
- Giving PermissionJournal of Clinical Oncology, 2008
- Glutathione S‐Transferase A1 Genetic Variants Reduce Busulfan Clearance in Children Undergoing Hematopoietic Cell TransplantationThe Journal of Clinical Pharmacology, 2008
- A Randomized, Double-Blind Comparison of the NK1 Antagonist, Aprepitant, Versus Ondansetron for the Prevention of Postoperative Nausea and VomitingAnesthesia & Analgesia, 2007
- Efficacy of oral casopitant mesylate, a novel neurokinin-1 receptor antagonist, with intravenous ondansetron HCl in the prevention of postoperative nausea and vomiting (PONV) in high-risk patientsEuropean Journal of Anaesthesiology, 2006
- Prevention of chemotherapy- and radiotherapy-induced emesis: results of the 2004 Perugia International Antiemetic Consensus ConferenceAnnals of Oncology, 2005
- Pharmacokinetics of palonosetron in combination with aprepitant in healthy volunteersCurrent Medical Research and Opinion, 2005
- Consensus Guidelines for Managing Postoperative Nausea and VomitingAnesthesia & Analgesia, 2003
- Pharmacology of the human metabolites of dolasetron, an antiemetic 5‐HT3 receptor antagonistDrug Development Research, 1995
- Comparison of the 5-Hydroxytryptamine3(Serotonin) Antagonist Ondansetron (Gr 38032F) with High-Dose Metoclopramide in the Control of Cisplatin-Induced EmesisNew England Journal of Medicine, 1990