Surface-Chemical Studies on Chlorhexidine and Related Compounds: 1. Effects at Air-Water, n-Hexane-Water, and Hydroxyapatite-Water Interfaces

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Abstract
The comparative ability of chlorhexidine diacetate and structurally related compounds to generate surface pressure at air-water and n-hexane-water interfaces, and to adsorb to hydroxyapatite, was determined. The order of effectiveness generally evident was 1-(p-chlorophenyl)-5-n-octylbiguanide acetate >> chlorhexidine diacetate ≥ 1-(p-chlorophenyl)-5-n-hexylbiguanide acetate > 1-(p-chlorophenyl )-5-n-propylbiguanide acetate > p-chlorophenylbiguanide acetate ~ p-chloro-phenylguanidine acetate.