Familial Alzheimer Disease-linked Presenilin 1 Variants Enhance Production of Both Aβ1–40 and Aβ1–42 Peptides That Are Only Partially Sensitive to a Potent Aspartyl Protease Transition State Inhibitor of “γ-Secretase”
Open Access
- 1 February 2003
- journal article
- Published by Elsevier
- Vol. 278 (9) , 7010-7018
- https://doi.org/10.1074/jbc.m209252200
Abstract
No abstract availableKeywords
This publication has 51 references indexed in Scilit:
- Presenilin 1 Mutations Activate γ42-Secretase but Reciprocally Inhibit ε-Secretase Cleavage of Amyloid Precursor Protein (APP) and S3-Cleavage of NotchJournal of Biological Chemistry, 2002
- Linear Non-competitive Inhibition of Solubilized Human γ-Secretase by Pepstatin A Methylester, L685458, Sulfonamides, and BenzodiazepinesJournal of Biological Chemistry, 2002
- Presenilins are not required for Aβ42 production in the early secretory pathwayNature Neuroscience, 2002
- Intramembrane Proteases--Mixing Oil and WaterScience, 2002
- Multiple Effects of Aspartate Mutant Presenilin 1 on the Processing and Trafficking of Amyloid Precursor ProteinJournal of Biological Chemistry, 2001
- The First Proline of PALP Motif at the C Terminus of Presenilins Is Obligatory for Stabilization, Complex Formation, and γ-Secretase Activities of PresenilinsPublished by Elsevier ,2001
- FAD Mutations in Presenilin-1 or Amyloid Precursor Protein Decrease the Efficacy of a γ-Secretase Inhibitor: Evidence for Direct Involvement of PS1 in the γ-Secretase Cleavage ComplexNeurobiology of Disease, 2000
- L-685,458, an Aspartyl Protease Transition State Mimic, Is a Potent Inhibitor of Amyloid β-Protein Precursor γ-Secretase ActivityBiochemistry, 2000
- Improved electrophoretic separation and immunoblotting of beta‐amyloid (Aβ) peptides 1–40, 1–42, and 1–43Electrophoresis, 1997
- Metabolism of the “Swedish” Amyloid Precursor Protein Variant in Neuro2a (N2a) CellsJournal of Biological Chemistry, 1996