Synthesis of some methoxy- and hydroxy-phenazine-1-carboxylic acids

Abstract
The synthesis of the naturally occuring 6- and 9-hydroxyphenazine-1-carboxylic acids, (3) and (4), is described. Methyl 6-methoxyphenazine-1-carboxylate (12) is identified as a metabolite from Streptomyces luteoreticuli, and a metabolite of Pseudomonas aureofaciens is identified as 2-hydroxyphenazine-1-carboxylic acid (2) by comparison with synthetic material.