New hope for an aids vaccine
- 1 April 2002
- journal article
- review article
- Published by Springer Nature in Nature Reviews Immunology
- Vol. 2 (4) , 239-250
- https://doi.org/10.1038/nri776
Abstract
The twenty-first century has begun with considerable success for new AIDS vaccines in macaque models. A common feature of these vaccines is their ability to induce high-frequency CD8+ T-cell responses that control, rather than prevent, infection with HIV. The new vaccines, which include DNA vaccines and live viral vectors, are based on technologies that have been developed since the start of the AIDS epidemic. The ultimate promise of these vaccines will be realized only when efficacy trials in humans are conducted.Keywords
This publication has 104 references indexed in Scilit:
- Protection against Simian Immunodeficiency Virus Vaginal Challenge by Using Sabin Poliovirus VectorsJournal of Virology, 2001
- Safety of 2 Recombinant Human Immunodeficiency Virus Type 1 (HIV-1) Envelope Vaccines in Neonates Born to HIV-1-Infected WomenClinical Infectious Diseases, 2001
- Production of recombinant adeno-associated virus vectors using a packaging cell line and a hybrid recombinant adenovirusGene Therapy, 1999
- Inhibition of HIV-1 Infection by the β-Chemokine MDCScience, 1997
- Reverse Transcriptase Fidelity and HIV-1 VariationScience, 1997
- Controlling HIV pathogenesis: the role of the noncytotoxic anti-HIV response of CD8+ T cellsImmunology Today, 1996
- Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infectionNature, 1995
- Heterologous Protection Against Influenza by Injection of DNA Encoding a Viral ProteinScience, 1993
- Complete nucleotide sequence of the AIDS virus, HTLV-IIINature, 1985
- Isolation of a T-Lymphotropic Retrovirus from a Patient at Risk for Acquired Immune Deficiency Syndrome (AIDS)Science, 1983