Sporidesmins. Part XII. Isolation and structure of sporidesmin G, a naturally-occurring 3,6-epitetrathiopiperazine-2,5-dione
- 1 January 1972
- journal article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- p. 470-472
- https://doi.org/10.1039/p19720000470
Abstract
When the tail fractions from chromatograms of sporidesmin E(I; n= 3) were rechromatographed, a new crystalline metabolite of Pithomyces chartarum was isolated with molecular formula C18H20ClN3O6S4. The new compound, named, sporidesmin G (I; n= 4), gave sporidesmin (I; n= 2) on irradiation or treatment with triphenylphosphine, and sporidesmin D (V) after reduction and methylation. It was shown that the model compound, 1,4-dimethyl-3,6-epidithiopiperazine-2,5-dione, gave the cyclic tetrasulphide on treatment with dihydrogen disulphide. Similarly, sporidesmin and sporidesmin E when treated with dihydrogen disulphide gave the new metabolite.Keywords
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