Sodium arsenite potentiates the clastogenicity and mutagenicity of dna crosslinking agents
- 1 January 1986
- journal article
- research article
- Published by Wiley in Environmental Mutagenesis
- Vol. 8 (1) , 119-128
- https://doi.org/10.1002/em.2860080111
Abstract
To see if sodium arsenite enhances the clastogenicity and the mutagenicity of DNA crosslinking agents, Chinese hamster ovary (CHO) cells and human skin fibroblasts were exposed to cis‐diamminedichloroplatinum (II) (cis‐Pt(II)) or 8‐methoxypsoralen (8‐MOP) plus long‐wave ultraviolet light (UVA) and then to sodium arsenite. The results indicate that the clastogenicity of cis‐Pt(II) and 8‐MOP plus UVA are enhanced by the post‐treatment with sodium arsenite. Chromatid breaks and exchanges are predominantly increased in doubly treated cells. Furthermore, the mutagenicity of cis‐Pt(II) at the hypoxanthine‐guanine phosphoribosyl transferase locus is also potentiated by sodium arsenite in CHO cells.Keywords
This publication has 39 references indexed in Scilit:
- Sodium arsenite enhances the cytotoxicity, clastogenicity, and 6-thioguanine-resistant mutagenicity of ultraviolet light in Chinese hamster ovary cellsMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1985
- Tumorigenicity of arsenic trioxide to the lung in Syrian golden hamsters by intermittent instillationsCancer Letters, 1983
- Studies of DNA and Chromosome Damage in Skin Fibroblasts and Blood Lymphocytes from Psoriasis Patients Treated with 8-Methoxypsoralen and UVA IrradiationJournal of Investigative Dermatology, 1983
- Arsenic and SCE in human lymphocytesMutation Research Letters, 1983
- 3-Aminobenzamide synergistically increases sister-chromatid exchanges in cells exposed to methyl methanesulfonate but not to ultraviolet lightMutation Research Letters, 1982
- Mutagenic responses of five independent geentic loci in CHO cells to a variety of mutagensMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1982
- The use of inhibitors of DNA repair in the study of the mechanisms of induction of chromosome aberrationsCytogenetic and Genome Research, 1982
- Enhancement of UV-mutagenesis by low concentrations of arsenite in E. coliMutation Research Letters, 1981
- Effects of sodium arsenite on single-strand DNA break formation and post-replication repair in E. coli following UV irradiationMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1980
- Chromosome aberrations in workers exposed to arsenic.Environmental Health Perspectives, 1977