Experimental Hydro-uteri (Hydrometra) in Rodents and Some Factors Determining Their Formation.

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Abstract
Ligation of the cervix uteri in mice, rats and hamsters was followed within 21 days by distension of the uterine horns (hydro-uterus, hydrometra) and repeated aspiration yielded as much as 100 ml of hydrouterine fluid from a single mouse during a year''s time. Histological study of hydrouteri shows absence of inflammatory changes and normal response to estrogenic stimulation. Hydrouterine fluid contains larger amounts of mucopolysaccharides and less proteins than does ascitic fluid. Castration delays the formation of hydrouteri and estrogens restore this rate to normal. Time is an important factor, with distension of the ligated uterus sometimes appearing only months after ligation. Aside from their value as a source of endometrial secretions hydrouteri are excellent sites for tumor transplantation.

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