Late Somatic Effects of X-Radiation in Mice Treated with AET and Isologous Bone Marrow

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Abstract
Young adult female mice were exposed to X-ray doses (350 to 1800 r), with or without treatment by AET or isologous bone marrow. Life span shortening varied with radiation dose, but the degree of life-shortening per ro-entgen decreased with increasing dose. Although AET and IBM had markedly protective effects against early lethality, their effectiveness in protecting against reduction of longevity in long-term survivors was equivocal. Tumors of ovary, lung, uterus, and/or breast appeared in sixty-six % of controls. Ovarian and mammary tumors were more numerous after irradiation. AET and IBM did not alter this incidence. Thymic lymphomas and myeloid leukemia were increased by irradiation. The incidence of other neoplasms of blood-forming elements was reduced in irradiated animals. AET and IBM inhibited the induction of thymic lymphomas. Glomerulo-sclerosis occurred in heavily irradiated survivors. The incidence was not affected by AET or IBM. Graying of the fur varied with the dose and was reduced by AET. The rapidity of onset, rate of progression, and final severity of lens opacities increased with increasing dose of X-rays and was not detectably affected by AET or IBM. AET and IBM protected against some but not all delayed somatic effects of whole-body X-irradiation.