Clusterin expression can be modulated by changes in TCF1-mediated Wnt signaling
Open Access
- 16 July 2007
- journal article
- Published by Journal of Molecular Signaling in Journal of Molecular Signaling
- Vol. 2 (1) , 6
- https://doi.org/10.1186/1750-2187-2-6
Abstract
Clusterin (CLU) is an enigmatic molecule associated with various physiological processes and disease states. Different modes of cellular stress lead to increased CLU levels, and additionally numerous growth factors and cytokines affect the expression of the CLU gene. APC and c-MYC, both intimately linked to the Wnt signaling pathway have previously been shown to influence CLU levels, and we therefore investigated if changes in Wnt signaling activity in vitro could regulate the expression of one, or more, of several CLU mRNA and protein variants.Keywords
This publication has 31 references indexed in Scilit:
- Up-regulation of the clusterin gene after proteotoxic stress: implication of HSF1–HSF2 heterocomplexesBiochemical Journal, 2006
- Challenge and promise: roles for clusterin in pathogenesis, progression and therapy of cancerCell Death & Differentiation, 2005
- Clusterin inhibits apoptosis by interacting with activated BaxNature Cell Biology, 2005
- Delayed Activation of Insulin-like Growth Factor-1 Receptor/Src/MAPK/Egr-1 Signaling Regulates Clusterin Expression, a Pro-survival FactorJournal of Biological Chemistry, 2005
- Synthesis and Functional Analyses of Nuclear Clusterin, a Cell Death ProteinJournal of Biological Chemistry, 2003
- Clusterin/Apolipoprotein J in human aging and cancerThe International Journal of Biochemistry & Cell Biology, 2002
- Clusterin gene transcription is activated by caudal-related homeobox genes in intestinal epitheliumAmerican Journal of Physiology-Gastrointestinal and Liver Physiology, 2001
- Direct Transactivation of the Anti-apoptotic Gene Apolipoprotein J (Clusterin) by B-MYBJournal of Biological Chemistry, 2000
- Transforming growth factor β regulates clusterin gene expression via modulation of transcription factor c‐FosEuropean Journal of Biochemistry, 1999
- Ram Rete Testis Fluid Contains a Protein (Clusterin) Which Influences Cell-Cell Interactions in Vitro 1Biology of Reproduction, 1983