The Adrenal Cortex and the Regulation of Water Exchange During Food Deprivation

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Abstract
Rats deprived of food but allowed water show an increased urine volume with a high spontaneous water intake. Adrenalectomized rats maintained with deoxycorticosterone acetate and deprived of food void a significantly lower volume of a more concentrated urine and have about half the water intake of deprived controls. The adrenalectomized rats, with this lower water turnover, show the same body weight changes and eliminate the same total solute load as the deprived controls. These results suggest that the spontaneous responses of the adrenal cortex to food deprivation affect water exchange by influencing the regulation of water intake.

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