Studies on v-triazoles. Part 4. The 4-methoxybenzyl group, a versatile N-protecting group for the synthesis of N-unsubstituted v-triazoles
- 1 January 1982
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 2,p. 627-630
- https://doi.org/10.1039/p19820000627
Abstract
A series of readily prepared monocyclic N-(4-methoxybenzyl)-v-triazoles (1) have been converted into their N-unsubstituted derivatives (2) by treatment with trifluoroacetic acid at 65 °C. The procedure allows the synthesis of a range of N-unsubstituted v-triazoles. Its applicability to multicyclic systems is demonstrated by the synthesis of 3,9-dihydro-9-oxobenzopyrano[2,3-d]-v-triazole (5b), one of a series of compounds of interest as potential antiallergic agents.This publication has 1 reference indexed in Scilit:
- Studies on v‐triazoles. Part II. Synthesis of 9‐oxo‐1H,9H‐benzopyrano[2,3‐d]‐v‐triazolesJournal of Heterocyclic Chemistry, 1981