Solubility of Cholesterol in Various Fats and Oils.

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Abstract
Summary The solubility of cholesterol in various fats and oils at 37°C has been studied using radioactive cholesterol. The amount of radioactivity present in the supernatant obtained after an excess of cholesterol-4-C14 and the fat have been shaken for 18 hours is used to assay the amount of cholesterol dissolved. Using both pure and natural triglycerides, it has been shown that the fats and oils composed largely of short chain fatty acids (C6- C12) have the greatest solubilizing effect. Addition of 2% of pure fatty acids (C6 through C20) to corn oil or coconut oil shows that while all the fatty acids used enhance cholesterol solubility, highest solubility is obtained when C6, C8, C10, or C12 fatty acids are used.

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