Mechanism of decreased insulinogenesis in manganese‐deficient rats Decreased insulin mRNA levels
- 19 October 1988
- journal article
- Published by Wiley in FEBS Letters
- Vol. 239 (1) , 55-58
- https://doi.org/10.1016/0014-5793(88)80544-1
Abstract
Manganese-deficient rats exhibited seven-fold lower preproinsulin mRNA levels compared to control, as detected by dot blot hybridization of both total and poly(A)+ RNA using a preproinsulin cDNA probe. No differences in the size of the insulin mRNA were observed. Thus, decreased mRNA levels may be a major contributing factor to the decreased insulinogenesis observed in manganese-deficient rats.Keywords
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