Lysophosphatidylcholine decreases single channel conductance of inward rectifier K channel in mammalian ventricular myocytes.
- 1 January 1984
- journal article
- Published by Physiological Society of Japan in The Japanese Journal of Physiology
- Vol. 34 (2) , 369-373
- https://doi.org/10.2170/jjphysiol.34.369
Abstract
Effect of lysophosphatidylcholine (LPC) on the inward rectifier K channel of the isolated guinea pig ventricular cell was studied using patch clamp technique. In that LPC (100 microM) decreased the magnitude of the single channel conductance from 48 +/- 5 pS (mean and S.D., n = 5) to 12 +/- 9 pS (n = 8), this event may be the prime factor related to the alleged LPC-induced depolarization of cardiac tissues.Keywords
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