Presence of D8/17 B-cell marker in patients with poststreptococcal reactive arthritis
- 13 January 2007
- journal article
- research article
- Published by Springer Nature in Rheumatology International
- Vol. 27 (8) , 695-698
- https://doi.org/10.1007/s00296-006-0296-z
Abstract
An elevated expression of the alloantigen D8/17 on B lymphocytes has been previously proposed as a susceptibility marker in rheumatic fever. The aim of the study was to investigate the presence of the D8/17 marker on B lymphocytes in poststreptococcal reactive arthritis (PSRA). The study sample included 19 patients (15 boys, 4 girls; mean age 11.7 ± 5.4 years) who were diagnosed with PSRA (mean age at diagnosis, 9.4 ± 5.6 years) and 18 healthy controls (10 boys and 8 girls) matched for ethnic background. B-cell D8/17 expression was tested by flow cytometry assay using monoclonal antibodies. Laboratory results showed a higher expression of D8/17 in the patient group (23.1 ± 10.4%, range 11.6–51.9%) than in the control group (17.1 ± 8.2%, range 7.1–35.7) in controls; this difference was statistically significant after log transformation of the data (P = 0.035). The high rate of expression of the D8/17 marker in patients with PSRA suggests that RF and PSRA share the same genetic susceptibility.Keywords
This publication has 14 references indexed in Scilit:
- B‐cell antigen D8/17 is a marker of rheumatic fever susceptibility in Aboriginal Australians and can be tested in remote settingsThe Medical Journal of Australia, 2006
- Poststreptococcal reactive arthritis: what is it and how do we know?Rheumatology, 2004
- Elevation of D8/17-positive B lymphocytes in only a minority of Dutch patients with post-streptococcal reactive arthritis (PSRA): a pilot studyRheumatology, 2002
- Poststreptococcal reactive arthritis in children: is it really a different entity from rheumatic fever?Rheumatology International, 2002
- Presence of the d8/17 B‐cell marker in children with rheumatic fever in IsraelClinical Genetics, 2002
- Acute rheumatic fever and poststreptococcal reactive arthritis: diagnostic and treatment practices of pediatric subspecialists in Canada.2001
- Poststreptococcal reactive arthritisCurrent Opinion in Rheumatology, 2000
- A flow cytometric assay for D8/17 B cell marker in patients with Tourette's syndrome and obsessive compulsive disorderJournal of Immunological Methods, 1998
- Update on complications of group A streptococcal infectionsCurrent Problems in Pediatrics, 1997
- Presence of a non-HLA B cell antigen in rheumatic fever patients and their families as defined by a monoclonal antibody.Journal of Clinical Investigation, 1989