Reduced coronary collateral resistances after chronic ventricular sympathectomy

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Abstract
Apparently chronic ventricular sympathectomy causes a reduction in coronary collateral resistances. An isolated dog heart procedure was used to directly measure directional collateral resistances in 12 acutely denervated controls and 8 hearts that underwent ventricular sympathectomy 2 wk earlier. The major coronary arteries were perfused separately but simultaneously during maximum vasodilation, and collateral resistances supplying the vascular beds of the arteries were determined by the double retrograde flow method. In the sympathectomized hearts, all collateral resistances were 47-65% less than in the controls (P < 0.05). In all hearts, minimum antegrade coronary resistances were determined from pressure-flow relationships in the major coronary arteries. Minimum coronary resistances in the 2 groups were not significantly different (P > 0.05). Apparently 2 wk of ventricular sympathectomy does cause a reduction in coronary collateral resistances, but has no effect on coronary resistances.